Each year, approx. 200,000 Americans lose their lives to trauma. After a traumatic injury, hemorrhage is responsible for over 35% of pre-hospital deaths and over 40% of deaths within the first 24 hours. A cascade of life-threatening medical conditions can occur simultaneously: 1) hemorrhage, 2) impaired resuscitation, 3) shock, 4) inflammation and 5) coagulopathy. Appropriate management of the massively bleeding trauma patient includes the early identification of bleeding sources followed by prompt measures to minimize blood loss, restore tissue perfusion, and to achieve       
hemodynamic stability.